This chapter explores the tension between public health protection and the freedom of commercial expression from a Commonwealth Caribbean perspective, using Barbados and Jamaica as case studies. First, it assesses the scope of the right to freedom of expression. Second, it discusses the extent to which public health protection may be invoked to restrict the right. The authors conclude that Commonwealth Caribbean states can justifiably restrict commercial speech about tobacco products and unhealthy food and beverages.

Increasingly, professionalism has been recognized as a core competency for health service professionals and is the domain in which vexing competence problems are observed in trainees. We begin by describing manifestations of problems of professionalism in accord with the values that fall within the rubric of this multifaceted construct. We provide an approach for evaluating problems of professionalism and discuss intervention for trainees with mild, moderate, or severe problems in this domain. We propose implications for training focused on enhancing the (...) culture of programs; bolstering the education, guidance, and mentoring provided related to professionalism; and encouraging best practices for addressing trainees with problems of professionalism. We conclude by sharing ideas about defining professionalism, identifying problems of professionalism, strengthening our approach to assessing professionalism and intervening when problems are evident, developing strategies for preventing professionalism problems, and ensuring that psychologists take seriously their responsibility to address professionalism concerns with colleagues. (shrink)

Warning research participants and patients about potential risks associated with participation/treatment is a fundamental part of consent. However, such risk warnings might cause negative expectations and subsequent nocebo effects (i.e., negative expectations cause negative outcomes) in participants. Because no existing review documents how past research has quantitatively examined nocebo effects – and negative expectations – arising from consent risk warnings, we conducted a pre-registered scoping review (N = 9). We identified several methodological issues across these studies, which in addition to (...) mixed findings, limit conclusions about whether risk warnings cause nocebo effects. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

This paper explores the events surrounding a string of robberies from the homes of young celebrities living in Los Angeles County by a group of teenagers referred to by the media as “The Bling Ring.” It argues that the group demonstrates the intersections of desire and materiality under the conditions of a culture driven by idolization of the celebrity, referring to the works of Jean Baudrillard, Pierre Bourdieu, and French collective Tiqqun. It further examines the events as a moment where (...) subjects were able to escape the life-narratives imposed upon them by the State. Rather than adhering to the norms of regular adolescent life, reproduced and enforced through what Michael Shapiro identifies as “national-time,” members of the Bling Ring endeavored to create their own lives according to what I refer to as “celebrity-time,” revealing processes of becoming in the work of Gilles Deleuze, and plasticity in that of Catherine Malabou. (shrink)

There are three potential problems with using virtue theory to develop an environmental ethic. First, Aristotelian virtue theory is ratiocentric. Later philosophers have objected that Aristotle’s preference for reason creates a distorted picture of the human good. Overvaluing reason might well bias virtue theory against the value of non-rational beings. Second, virtue theory is egocentric. Hence, it is suited to developing a conception of the good life, but it is not suited to considering obligations to others. Third, virtue theory is (...) notoriously bad at providing rules and procedures for resolving ethical questions about particular circumstances. But environmentalists need procedures for determining which of several conflicting values is most important. Virtue theory is not action guiding. I respond to each of these problems. I show that virtue theory is uniquely suited to answering ethical questions about nonhuman animals and the environment. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

This article reflects on the problem of false belief produced by the integrated psychological and algorithmic landscape humans now inhabit. Following the work of scholars such as Lee McIntyre (Post-Truth, MIT Press, 2018) or Cailin O’Connor and James Weatherall (The Misinformation Age: How False Beliefs Spread, Yale University Press, 2019) it combines recent discussions of fake news, post-truth, and science denialism across the disciplines of political science, computer science, sociology, psychology, and the history and philosophy of science that variously address (...) the ineffectiveness, in a digital era, of countering individual falsehoods with facts. Truth and falsehood, it argues, rather than being seen as properties or conditions attached to individual instances of content, should now be seen as collective, performative, and above all persuasive phenomena. They should be practically evaluated as networked systems and mechanisms of sharing in which individually targeted actions are combining with structural tendencies (both human and mechanical) in unprecedented ways. For example, the persuasive agency of apparent consensus (clicks, likes, bots, trolls) is newly important in a fractured environment that only appears to be, but is no longer ‘public’; the control of narratives, labels, and associations is a live, time-sensitive issue, a continuous contest, or ongoing cusp. Taking a social approach to truth yields observations of new relevance; from how current strategies of negative cohesion, blame, and enemy-creation depend crucially on binary ways of constructing the world, to how the offer of identity/community powerfully cooperates with the structural tendencies of algorithm-driven advertiser platforms towards polarisation. Remedies for these machine-learned and psychological tendencies lie in end-user education. So the Arts and Humanities, whether via comparisons with previous historical periods, or via principles of critical thinking and active reading, offer crucial resources to help counter what since 1997 silicon valley executives and scholars have called ‘persuasive technology’ (Fogg in Persuasive Technology: Using Computers to Change What we Think and Do, Morgan Kaufmann, 2003; Hamari et al. (eds) in Persuasive Technology, Springer International Publishing, 2014; Harris in How a Handful of Tech Companies Control Billions of Minds Every Day, 2017; Lanier in Who Owns the Future? Simon & Schuster, 2014 and Ten Arguments for Deleting your Social Media Accounts Right Now, Picador, 2019). The article proposes a paradigm shift in public understandings of this new social environment: from a culture of discovery, where what matters is what exists or is in fact the case, to a culture of iteration, where what matters is what gets repeated. (shrink)

This is a reprint of Amartya Sen’s 1973 book on the measurement of inequality, plus an updated bibliography and index, and an annex by James Foster and Sen that summarizes and comments on the main developments since 1973. The book is superbly written and focuses on verbal discussion of the plausibility and significance of the conditions, theorems, and measures.

Major depressive disorder is a highly prevalent psychiatric disorder, and recurrent depression is associated with severe and chronic impairment. Identifying markers of risk is imperative to i...

This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic research results to study participants. Pharmacogenetics and disease genetics studies are becoming increasingly prevalent, leading to a growing body of information on genetic associations for drug responsiveness and disease susceptibility with the potential to improve health care. Much of these data are presently characterized as exploratory (non‐validated or hypothesis‐generating). There is, however, a trend for research participants to be permitted (...) access to their personal data if they so choose. Researchers, sponsors, patient advocacy groups, ethics committees and regulatory authorities are consequently confronting the issue of whether, and how, study participants might receive their individual results. Noted international ethico‐legal guidelines and public policy positions in Europe and the United States are reviewed for background. The authors offer ‘Points‐to‐Consider’ regarding returning research results in the context of drug development trials based on their knowledge and experience. These considerations include: the clinical relevance of data, laboratory qualifications, informed consent procedures, confidentiality of medical information and the competency of persons providing results to participants. The discussion is framed as a benefit‐to‐risk assessment to balance the potential positive versus negative consequences to participants, while maintaining the integrity and feasibility of conducting genetic research studies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:In Search of the ClassicEdward E. FosterIn Search of the Classic, by Steven Shankman; xvi & 331 pp. University Park: Pennsylvania State University Press, 1995, $55.00 cloth, $18.95 paper.“In search of” in the title of a book is often a code warning of lukewarm conviction or academic disingenuousness. In Shankman’s title, however, the phrase is literally appropriate because he forthrightly argues that the classic is, of its nature, (...) something that always exists in quest and tension. The classic is not to be located merely in classical antiquity or in the tastes of a privileged class. Though Shankman grants that these often are associated with the literary classic, he finds the nature of the classic rather in the nature of literature as a state of metaxis or “in-betweenness.” His examinations of classical, neo-classical, and modern works define various aspects of this “in-betweenness,” the state of tension that exists in the truly classic at any point in the history of literature.Although Shankman dismisses Derrida, Foucault, de Man, and others for having mistaken their own destruction of Enlightenment rationalism for a demonstration that rationality is impossible, he is not wildly original. He uses Habermas’s notion of classic literature as enduring and independent of time and Vogelin’s concept of metaxis as foundational for his sprawling, yet lucid, inquiry into the idea of the classic in Homer, Plato, Aristotle, Pindar, Virgil, Dryden, Defoe, Swift, Valery, and others, and in the traditions of the epic, ode, pastoral, and lyric.Fundamental is the view that classic literature has the greatest power to represent human experience. To avoid the hermeneutical conundrum of the subject-object dilemma, Shankman asserts literature to be in “a middle place” from Plato and Aristotle on. He sees a basic agreement between them on how literature stands between the One and the Many. Put negatively, literature is not sparks from the One or compilations of the Many. Rather it is a mediator between these polarities: classic literature accommodates the propositional purity of philosophy to the indeterminacy of thing-reality. Literature is neither an abstract kernelization of truth nor an anthology of the things of experience [End Page 256] but an analogical conjunction of the two extremes—therefore tension, therefore continual quest.Using Plato, especially the Cratylus and the Symposium, and Aristotle, especially the Metaphysics and the Poetics, Shankman describes a rationality that exists in literature that is clearly identified in his chapter on Swift’s Gulliver’s Travels by emphasizing the idea of man as an animal capax rationis. This in itself places man’s literary enterprise in a middle place and Shankman explores its various implications in a variety of works. From this perspective, it is argued that literature must be about something that matters; that pure poetry or reflexive poetry cannot achieve the ambiguity of analogy as the central core that the classic requires. Thus, Plato never rejected poetry—only the debasement of poetry into either the fantastical or literal (or the confusion of the two.)The true classic walks a line between ignorance and knowledge, rhetoric and philosophy, literalism and fantasy, “thing-reality” and “the ideal.” The Aeneid makes a good test case. It is at once a piece of propaganda and a statement of an ideal that is complicated by the duplicity of Aeneas’ abandonment of Dido, the brutality of his killing of Turnus, and his emergence in Book VI from the underworld by the Gate of Ivory (false dreams). Such tension is exemplary of what Shankman sinuously argues is at the heart of “the classic” in a variety of other works.The argument is persuasive and attractive, even if not compelling, in a world where many critics would have us believe that all of literature, canonical or not, is disappearing into nontext. That about half of the chapters are adaptations of previously published articles risks a discontinuity that is largely avoided by recapitulations of where we are in the exposition of our struggle in a continuing and intrinsic state of rational metaxis. I like the idea, but I must reserve judgment on a thesis that attends to the poetry of Yvor Winters and E. V. Cunningham... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The French Tradition and the Literature of Medieval EnglandEdward E. FosterThe French Tradition and the Literature of Medieval England, by William Calin; xvi & 587pp. Toronto: University of Toronto Press, 1994, $75.00 cloth, $29.95 paper.Probably not many people will read all of this book, because it is very long. That is too bad, because it is also very good and its length is necessary for its double purpose: (...) to reconceptualize the connections between French and English literature in the Middle Ages and to provide sensitive interpretations both of familiar and of ignored Medieval narratives. The doubleness is neatly reciprocal: the readings grow into the revisionist definition of influence, and the notion of influence informs the individual readings.The innovative and persuasive argument that orders the whole book is that the impact of the French tradition has been too narrowly defined. Rather than simply retracing the influence of the classics of French fin amour, like Chrétien, on the corpus of Middle English literature, Calin sinuously argues the influence of Anglo-Norman and thirteenth and fourteenth century Central French works on the literature of the high English Middle Ages. From Anglo-Norman, Calin draws, predictably, on the lais of Marie de France. Less predictably, he draws on Beroul and Thomas of England and on romances like Ipomedon, Amadas et Ydione, and Gui de Warewic. Least predictably, he draws on the tradition of saints’ lives as formative of later Medieval moral narrative. From Central French, he draws, predictably, on the Roman de la Rose. Less predictably, but very convincingly, he draws on material frequently slighted even by French critics: Guillaume de Digulleville, the Prose Lancelot, Machaut, Froissart, and Chartier. But even more than influence, in the traditional sense, Calin persuasively demonstrates an enlivening intertextuality. He rescues Anglo-Norman classics from their stodgy reputation and late Central French texts from inattention and makes both relevant to the development of the English narrative tradition in court poetry and in popular romance.The power of Calin’s overarching argument depends heavily on the critiques of individual works. Without forgetting Chrétien and the earlier French tradition, he traces in Marie, Beroul, and Thomas, the formation and complication of fin amour which were present and available to English writers. He describes the narrative force of Anglo-Norman saints’ lives on the fictional techniques of English romance. His acute treatment of interlace in the Prose Lancelot reveals the treasure trove that English romancers could draw on, for technique as well as themes. In addition, he shows both how de Digulleville served up the “dream vision” and Machaut and Froissart served up the limited, even bumbling, narrator for fourteenth-century England.It could be argued that Calin’s method of doing very modern or postmodern analyses of early French poetry and prose is misleading. And it is true that some of the readings of French texts seem eccentric. For example, the relentless imposition of Freud on Marie is perplexing even when plausible. One wonders [End Page 400] whether this is the best way to approach the Lais. And Calin moves on to feminist, and old and new historicist readings of other texts. Each is well done, but it is sometimes hard to tell which way the winds of theory are blowing and why. While it must be granted that the interpretations of Middle English romances, like Ywain and Gawain, Amis and Amiloun, and William of Palerne, are not profoundly different from what other scholars have come to, there is no denying that embedding them in their French contexts gives them a richness they ordinarily lack. Even more laudable is the way in which influence is elaborated not just as a matter of themes but as a transformation of techniques and even sensibility.My greatest reservation is the treatment of Chaucer, especially “The Franklin’s Tale.” Calin does recognize Chaucer’s debts to the classics (though mostly through the Ovid Moralisé) and to the Italians. Yet Chaucer is the one author for whom the weight of French intertextuality seems less a determinant than a stimulant. In “The Franklin’s Tale,” the French burden leads to a reading that too easily dismisses both ironic... (shrink)

ABSTRACT This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic research results to study participants. Pharmacogenetics and disease genetics studies are becoming increasingly prevalent, leading to a growing body of information on genetic associations for drug responsiveness and disease susceptibility with the potential to improve health care. Much of these data are presently characterized as exploratory (non‐validated or hypothesis‐generating). There is, however, a trend for research participants to be (...) permitted access to their personal data if they so choose. Researchers, sponsors, patient advocacy groups, ethics committees and regulatory authorities are consequently confronting the issue of whether, and how, study participants might receive their individual results. Noted international ethico‐legal guidelines and public policy positions in Europe and the United States are reviewed for background. The authors offer ‘Points‐to‐Consider’ regarding returning research results in the context of drug development trials based on their knowledge and experience. These considerations include: the clinical relevance of data, laboratory qualifications, informed consent procedures, confidentiality of medical information and the competency of persons providing results to participants. The discussion is framed as a benefit‐to‐risk assessment to balance the potential positive versus negative consequences to participants, while maintaining the integrity and feasibility of conducting genetic research studies. (shrink)

While philosophers have worried about mental causation for centuries, worries about the causal relevance of conscious phenomena are also increasingly featuring in neuroscientific literature. Neuroscientists have regarded the threat of epiphenomenalism as interesting primarily because they have supposed that it entails free will scepticism. However, the steps that get us from a premise about the causal irrelevance of conscious phenomena to a conclusion about free will are not entirely clear. In fact, if we examine popular philosophical accounts of free will, (...) we find, for the most part, nothing to suggest that free will is inconsistent with the presence of unconscious neural precursors to choices. It is only if we adopt highly non-naturalistic assumptions about the mind (e.g. if we embrace Cartesian dualism and locate free choice in the non-physical realm) that it seems plausible to suppose that the neuroscientific data generates a threat to free will. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.2 (2001) 364-367 [Access article in PDF] Book Review Hamlet in Purgatory Hamlet in Purgatory, by Stephen Greenblatt; xii & 322 pp. Princeton: Princeton University Press, 2001, $29.95. Hamlet in Purgatory is both more and less than literary criticism of Shakespeare's most haunting and most critically belabored play. Greenblatt has captured an evolving culture of belief which informs the play and goes far beyond source studies (...) or the history of ideas. He assays to show how the Medieval doctrine of Purgatory and the rejection of it by Protestant Reformers shaped the structure of Hamlet and the world of Hamlet's spiritual agony.Central to the argument is the notion that the rejection of Purgatory, and ritual practices associated with the doctrine, threatened to disrupt community and sever the relations between the living and the dead. Thus, the senior Hamlet's plea to "Remember me" takes precedence over his injunction to revenge; traditional preoccupations of Hamlet criticism become secondary to the concern for spiritual community which Reformation doctrine threatened. The exegesis is scholarly and the prose is engaging, yet the book suffers from the new historicist tendency to become absorbed more with context than with criticism and to assume too readily the relevance of the context to the criticism. Put another way, Greenblatt, like other new historicists, is not always rigorous in his inferences.Greenblatt warns that his book "requires a certain hermeneutical patience, a willingness to suspend direct literary analysis, in order to examine more thoroughly what has been treated as mere background for the canonical work of art" (p. 5). Although the book culminates in a description of the migration of discarded religious ritual into the theater, and a thoughtful commentary on Hamlet, Greenblatt cautions that "... for the book to work properly, the reader should understand literary analysis, and specifically the analysis of Hamlet, to be suspended in another sense as well, that is, distributed in tiny, almost invisible particles throughout my account" (p. 5). Amen. The caveats are essential for anyone who might expect an "interpretation" of Hamlet. Rather, Greenblatt has evoked the conflict of enduring beliefs and Reformist critiques which animated Shakespeare's imagination and Hamlet's suffering.Hermeneutical patience certainly is demanded of the reader, because more than half of the book presents commentaries on the doctrine of Purgatory from the late Middle Ages to the early seventeenth century. Greenblatt begins with Simon Fish's 1529 "Supplication for the Beggars," (p. 15) an anti-purgatorial (and anti-clerical) tract addressed to Henry VIII. Fish argued that the doctrine of Purgatory is at the heart of ecclesiastical corruption and is a danger to the state, because the fear that the doctrine can generate enables the clergy to extort enormous wealth in the form of "suffrages," donations for trentals, anniversary Masses, and other perpetual penitential memorials on behalf of the dead. Fish's argument is double: its theological burden is that Purgatory is a non-scriptural superstition; its rhetoric is that it is an abuse of the [End Page 364] poor and a danger to the economic solvency of the kingdom. Fish invokes both doctrinal error and political danger; this is thus an excellent tract to begin the elucidation of the complexity of Reformist objections to Purgatory in sixteenth-century England. Greenblatt adds that other Reformers saw Purgatory as a poetic creation, a fable, and therefore a vain imagining. John Donne's "Devotions upon Emergent Occasions" is cited to show that post-Catholic divines believed that purgation must be completed in this life.According to Greenblatt, an unintended consequence for the laity of the rejection of Purgatory is the creation of a radical divide between the living and the dead. If we pray for the dead, they are not as absent from us as if they had passed on to the timeless worlds of Heaven or Hell. Even if Purgatory is expensive or fabulous, its loss destroys a community with the dead that involved a reciprocal and continuing relationship, whereby the living can aid the dead towards Heaven and saved souls can eventually become intercessors in Heaven for the living... (shrink)

Tort claims have been studied for various reasons. Several studies have found that most tort claims are not related to negligent adverse events and most negligent adverse events do not result in tort claims. Several studies have examined the disposition of tort claims to understand the likelihood of payment once a claim has been made. Still others have proposed that tort-claims trend analysis may help administrators target their quality-improvement efforts and identify problems with quality that would not otherwise be captured.In (...) this article, we conduct a tort-claims analysis to explore areas for quality improvement, specifically for patient safety, in the Veterans Health Administration. Patient safety is an increasingly highlighted aspect of health-care delivery. Failure to assure patient safety can result in bad clinical outcomes, additional costs of care, and a negative organizational image. Filing a tort claim is one way for an individual to express concern about an organization. For our analysis, we draw from resolved tort claims in the Veterans Health Administration from fiscal years 1989 to 2000. (shrink)

Tort claims have been studied for various reasons. Several studies have found that most tort claims are not related to negligent adverse events and most negligent adverse events do not result in tort claims. Several studies have examined the disposition of tort claims to understand the likelihood of payment once a claim has been made. Still others have proposed that tort-claims trend analysis may help administrators target their quality-improvement efforts and identify problems with quality that would not otherwise be captured.In (...) this article, we conduct a tort-claims analysis to explore areas for quality improvement, specifically for patient safety, in the Veterans Health Administration. Patient safety is an increasingly highlighted aspect of health-care delivery. Failure to assure patient safety can result in bad clinical outcomes, additional costs of care, and a negative organizational image. Filing a tort claim is one way for an individual to express concern about an organization. For our analysis, we draw from resolved tort claims in the Veterans Health Administration from fiscal years 1989 to 2000. (shrink)

Unlock the secrets of the art world and unleash your creative potential with this innovative and inspiring book. Drawing on the principles of vital art education, this book offers a fresh approach to art instruction that emphasizes the importance of creativity, experimentation, and personal expression. Full of practical tips, engaging exercises, and stunning examples of art, this book is a must-read for artists of all levels and backgrounds. This work has been selected by scholars as being culturally important, and is (...) part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Despite the burgeoning literature on professionalism in other health professions, psychology lags behind in the level of attention given to this core competency. In this article, we review definitions from other health professions and how they address professionalism. Next, we review how this competency evolved within health service psychology (HSP), and we propose a definition. We offer an approach for assessing professionalism within HSP. Consideration is given to strategies and methods for providing effective education and training in this multifaceted competency. (...) Finally, recommendations are made for creating a culture of professionalism within HSP and honoring psychology’s social contract with multiple publics. (shrink)

Researchers rely on psychometric principles when trying to gain understanding of unobservable psychological phenomena disconfounded from the methods used. Psychometric models provide us with tools to support this endeavour, but they are agnostic to the meaning researchers intend to attribute to the data. We define method effects as resulting from actions which weaken the psychometric structure of measurement, and argue that solution to this confounding will ultimately rest on testing whether data collected fit a psychometric model based on a substantive (...) theory, rather than a search for a model that best fits the data. We highlight the importance of taking the notions of fundamental measurement seriously by reviewing distinctions between the Rasch measurement model and more generalised 2PL and 3PL IRT models. We then present two lines of research that highlight considerations of making method effects explicit in experimental designs. First, we contrast the use of experimental manipulations to study measurement reactivity during the assessment of metacognitive processes with factor-analytic research of the same. The former suggests differential performance-facilitating and -inhibiting reactivity as a function of other individual differences, whereas factor-analytic research suggests a ubiquitous monotonically predictive confidence factor. Second, we evaluate differential effects of context and source on within-individual variability indices of personality derived from multiple observations, highlighting again the importance of a structured and theoretically grounded observational framework. We conclude by arguing that substantive variables can act as method effects and should be considered at the time of design rather than after the fact, and without compromising measurement ideals. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The informed consent process presents challenges for psychological trauma research (e.g. Institutional Review Board [IRB] apprehension). While previous research documents researcher and IRB-member perspectives on these challenges, participant views remain absent. Thus, using a mixed-methods approach, we investigated participant views on consent guidelines in two convenience samples: crowdsourced (N = 268) and undergraduate (N = 265) participants. We also examined whether trauma-exposure influenced participant views. Overall, participants were satisfied with current guidelines, providing minor feedback and ethical reminders for researchers. Moreover, (...) participant views for consent were similar irrespective of trauma-exposure. Our study has implications for IRBs and psychological researchers. (shrink)